Our proposal for the new Joint Research Centre (JRC) promotes a human centered and innovative design concept which aims to set a new benchmark for sustainability and inclusion, contributing positively to the transformation of the urban and social environment on Cartuja Island. Located on the old site of the EXPO 92, the new JRC reacts on the historic city on the other side of the river and is perceived as an open hand with five “fingers” and one vertical element – the tower – which provides a recognizable welcoming gesture when seen from afar. The building mixes in an unexpected way the presence of nature as part of the Andalusian city with the principles of the old city center: narrow streets, protected outdoor meeting points, traditional shading devices, covered walkways and distinctive vegetation, creating a unique contemporary work ecosystem. Focusing on the well-being of the researcher in contact with the natural environment of the reminiscent traditional patios, we propose a new office concept based on a more domestic and flexible way of working which is materialized through a series of spaces which can be extended into the exterior. For this reason, different indoor-outdoor situations are proposed: from enclosed open air individual work to meetings on terraces for collaborative work or relaxation in a yoga session exercised in one of the multipurpose rooms with access to the garden. Taking advantage of the topography of the site, a careful landscape design and an optimized position of the building volumes, generate a large park enhancing microclimates in the different patios. The bioclimatic concept is based on vernacular construction methods, and developed through a low-tech strategy, learning from the typical Sevillian streetscape in which the traditional window blinds and the textile shading spanning between buildings contribute to the distinct urban environment. Thanks to this combination, each user can regulate their relationship with the exterior according to their needs, converting the façades into colorful mosaics that reveal the changing activities in the interior according to the climatic conditions during the day. Nevertheless, the project makes use of the latest tendencies in sustainable construction. The structural system of the building, uses cross laminated timber (CLT) panels, prefabricated, and mounted in dry construction technique with repetitive and interchangeable elements, allowing for multiple configurations and maximum flexibility for future uses. In the case of the Tower, with a greater solar incidence, the façade is using a unitized curtain wall system, optimizing insolation, and simplifying the process of assembly on site. Therefore, we can conclude that the new JRC achieves the requirements of “The New European Bauhaus”, proposing a “beautiful” building without renouncing to contemporary esthetic qualities while looking for new urban relationships and landscape integration, “sustainable” for the intentional harmony between traditional and contemporary construction systems; and ‘inclusive’ for proposing a new concept of collaborative office that coexists on the exterior.